xSPECT Quant Sensitivity/Cross Calibration Procedure Job Aid

xSPECT Quant Sensitivity/Cross Calibration Procedure SPECT/CT Description: This step by step procedure will guide the user in performing sensitivity and cross calibration procedures necessary for the accurate quantification of xSPECT studies. What You Will Need: Co57 xSPECT Calibration/Peaking Source Kit (for use with LEHR and LPHR collimators) Note: If your scanner has Automatic Quality Control (AQC), your kit will not have a peaking source. The name of the kit is Co57 xSPECT Calibration Source Kit. SIEMENS Se75 xSPECT Calibration/Peaking Source Kit (for use with MELP collimators) SIEMENS 2 3 Cross Calibration Source (peaking and calibration sources for respective clinical isotope to be calibrated) Effective Date: 08/21/2018 | HOOD05162002934310 SIEMENS siemens.com/healthineers Healthineers Job Aid | xSPECT Quant Sensitivity/Cross Calibration Effective Date: 08/21/2018 | HOOD05162002934310 Performing the xSPECT Sensitivity Procedure: Description: In order to enable xSPECT Quant acquisitions, the system must be calibrated with the following calibration procedure. Siemens recommends these calibrations to be performed once a month. Overview of Procedure Tuning and Peaking Tuning is a calibration that adjusts the gains of the PMTs · Peaking shifts the analyzer window that it is centered around the actual energy peak as · detected by the camera. Sensitivity Calibration The sensitivity calibration measures the difference between the system’s ability to detect the · radioactivity and the true amount of radioactivity using a precision source and collimator. Cross Calibration The cross calibration measures dose calibrator bias using a measured point source and · collimator. This step is optional but recommended as it enables unbiased SUV quantification. Steps to Perform Procedure Sensitivity Calibration or Cross Calibration 1. Home the system and remove the collimators 2. Mount the peaking source. a. Unscrew vial holder cap from the end of the integrated source holder b. Loosen thumb screw on the top of peaking source c. Slide peaking source over end of the source holder d. Remove the calibration source from the room e. If performing the Cross Calibration, place the peaking source in the holder 3. On the syngo MI Acquisition Workplace, register or select the patient and launch the Sensitivity Calibration workflow or Cross Calibration workflow that is located in the Calibration category. 4. Peak the system a. Camera Parameters Tab b. Select the appropriate camera preset from the pulldown menu Sensitivity Calibration Se75 – SC-Se75-LME-NMG • Co57 – SC-Co57-NMG • Cross Calibration Tc99m – SC-Tc99m-NMG · In111 – SC-In111-NMG · I 123 SC-I123-NMG · – *Lu177 – SC-Lu177-208 NMG · c. Go to the Analyzer Tab d. Peak the camera e. Put away peaking source f. Install the collimators Siemens Healthineers Services Page 2 of 6 Job Aid | xSPECT Quant Sensitivity/Cross Calibration Effective Date: 08/21/2018 | HOOD05162002934310 5. Sensitivity Calibration: If this is the first time that you are using this source, you need to next enter the Precision Source Registration a) Select the Analyzer tab b) Select the Source Management tab c) Select Entry Type from pull down d) Label Menu: Enter source serial number e) Assay: i. Enter dose information from system apparent activity on source label ii. Assay Date iii. Make sure correct isotope is selected on the Camera Parameters tab iv. Save. Your registered source will show in the Registered Labels pull down menu Parameters Stop Conditions| Source Mgmt Registered Labels: New Item Entry Type: 75 Selenium Dose Calibrator 75 Selenium Label: 57 Cobalt Assay Dose: 0 MBq 8/ 4/2016 Save Delete f) Navigate to the Series Information Tab and go to the Calibration Source menu. Select the precision source you are using. Summary Series Information Camera Parameters Stop ConditD Series: Technologist Reading Physician Referring Physician Organ: Calibration Source Isotope: Label 75 Selenium Dose: 0 MBq M6-483 &/ 4/2016 12:00:00 AM 6. Cross Calibration: If this is the first time you are using a particular dose calibrator, you need to next enter the Dose Calibrator Registration. a. Go back to the Source Management tab b. Enter the dose calibrator name in the Label field c. Make sure the correct isotope is selected on the Camera Parameters tab d. Save Camera Parameters Stop Conditions Source Mgmt Registered Labels: New Item Entry Type: Dose Calibrator Label DC11 Assay Dose: 0 MBG 8/ 4/2016 Save Delete Siemens Healthineers Services Page 3 of 6 Job Aid | xSPECT Quant Sensitivity/Cross Calibration Effective Date: 08/21/2018 | HOOD05162002934310 e. Navigate to the Series Information Tab and go to the Calibration Source menu. Select the dose calibrator used to measure the point source. 7. Install the Calibration source. a. Screw the source to the end of the integrated source holder b. Active element is contained in the sphere at the pointed end of the calibration source c. Position the active element over the center of the detectors d. If you are preforming the Cross Calibration, install the point of the isotope into the end of the integrated source holder e. Position the activity in the vial over the center of the detectors 8. Acquire the Sensitivity/Cross Calibration a. Press Prepare Acquisition System initiates motion to the position the detectors with a 10 cm source to · collimator distance b. Press Start Acquires an uncorrected image for both detectors simultaneously · Proceeds to Sensitivity Calculation activity · Camera Parameters Camera Parameters Supine Supine 1024 X 1024 1024 × 1024 1.0 1.0 SC-Tc99m-NMG Done SC-Tc99m-NMG Both Detectors Both Detectors Done Prepare Acquisition Prepare Acquisition Siemens Healthineers Services Page 4 of 6 Job Aid | xSPECT Quant Sensitivity/Cross Calibration Effective Date: 08/21/2018 | HOOD05162002934310 9. Sensitivity Calculation Activity a. Processes the Calibration data b. Review the following: Patient · Collimator · Isotope · Presets · Crystal Thickness · c. Photopeak menu à Photopeak Measured sensitivity results are displayed · If results acceptable à Accept These Calibrations and Make Them Current · If results not acceptable à Reject These Calibrations and Use Existing Set · Sensitivity Calibration Patent 20160510_Bay6_SensCalb_MELP_Se75 Collmator. Medium-Energy, Low.Penetration Isotope: 75 Selenium Preset SC.Se75-LMENMG session 75 Selenium 133 kev Crystal 3/8" Sensitivity- Nomnat 86 8 ensitivity Measured 940 CPSNES Sensitivity - Nominal 86.8 CPSAMEN Sensitivity - Measured 93.4 Deviation from Normat 8 3 Deviation from Nominal 7,7 Reject These Calbrations and Use Existing Set d. Select Complete Image data and Sensitivity Calculation save screen are saved to the patient database • e. Remove calibration source f. Retract integrated source holder 10. Review the Sensitivity Calibration Dashboard. a. A calibration dashboard is available on the Series Information tab to show available calibration for collimators and presents Series Information Camera Parameters Stop Conditions Soure <> Senes Technologist Reading Physicien Referring Physician Organ Calibration Source Isotope Label 99m Technedum Dose Time Mq 8/ 4/2016 - 12:00:00 AM Coni .. Preset Source ID LPHR SC-Co57-NMG N1-641 LPHR SC-Tc99m-NMG N1-641 LPHR SC-1123-NMG N1-641 MELP SC-Se75-LME-NMG M6-483 10 um-18 N MELP SC-1123-NMG MB-483 MELP SC-Lu177-208-NMG M6-483 MELP SC-In 111-NMG M6-483 LEHR SC.Co57-NMG N1-641 LEHR: SC-Tc99m-NMG N1-641 *xSPECT Quant 177Lu is not commercially available in some countries, including the US. 177Lu is not currently recognized by the US FDA as being safe and effective, and Siemens does not make any claims regarding its use. Due to regulatory reasons, its future availability cannot be guaranteed. Please contact your local Siemens organization for further details. Siemens Healthineers Services Page 5 of 6 Job Aid | xSPECT Quant Sensitivity/Cross Calibration Effective Date: 08/21/2018 | HOOD05162002934310 Please note that the learning material is for training purposes only! For the proper use of the software or hardware, please always use the Operator Manual or Instructions for Use (herein- after collectively “Operator Manual”) issued by Siemens Healthineers. This material is to be used as training material only and shall by no means substitute the Operator Manual. Any material used in this training will not be updated on a regular basis and does not necessarily reflect the latest version of the software and hardware available at the time of the training. The Operator's Manual shall be used as your main reference, in particular for relevant safety information like warnings and cautions. Note: Some functions shown in this material are optional and might not be part of your system. Certain products, product related claims or functionalities (hereinafter collectively “Functionality”) may not (yet) be commercially available in your country. Due to regulatory requirements, the future availability of said Functionalities in any specific country is not guaranteed. Please contact your local Siemens Healthineers sales representative for the most current information. The reproduction, transmission or distribution of this training or its contents is not permitted without express written authority. Offenders will be liable for damages. All names and data of patients, parameters and configuration dependent designations are fictional and examples only. All rights, including rights created by patent grant or registration of a utility model or design, are reserved. Copyright © Siemens Healthcare GmbH 2018 ………………………………………………………… Siemens Healthineers Headquarters Siemens Healthcare GmbH Henkestr. 127 91052 Erlangen, Germany Telephone: +49 9131 84-0 siemens.com/healthineers Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2018