Tips & Tricks: Using EQ•PET to Measure Across Multiple Technologies

Customer Care Tips & Tricks: Using EQ•PET to Measure Across Multiple Technologies Available on all Biograph™ mCT scanners, Siemens’ exclusive EQ•PET algorithm harmonizes quantified PET data based on EANM, SNMMI and RSNA recommendations. By Matthew Kelly, PhD, Molecular Imaging Business Unit, Siemens Healthcare EQ•PET allows standardized uptake Reconstruction EQ Parameter (mm) by Post-filter (mm) value (SUV) comparison in longitudinal 1 2 3 4 5 patient exams for assessment of dis- OSEM 2i24s 6.0 5.9 5.5 4.6 3.6 ease manifestation and change–in- dependent from the scanner make, 3i8s 3.8 3.7 3.2 0.0 0.0 model or reconstruction algorithms. 3i24s 6.0 5.9 5.5 4.6 3.6 Therefore, this algorithm can measure 4i8s 5.1 5.0 4.6 3.8 2.2 across multiple and differing technol- ogies. To measure SUV across multiple 4i24s 6.0 5.9 5.5 4.6 3.5 technologies, follow these four steps: TOF 2i21s 6.0 6.0 5.5 4.7 3.6 3i21s 6.0 5.9 5.6 4.8 3.5 (1) Calculate EQ•PET Parameters 4i21s 6.0 6.0 5.6 4.8 3.4 First, the EQ•PET parameter for your scanner and preferred reconstruction HD•PET 2i24s 6.5 6.4 6.1 5.3 4.3 protocol should be calculated. In 3i8s 5.9 5.8 5.4 4.6 3.6 agreement with the EANM guidelines, 3i24s 7.4 7.4 7.0 6.4 5.6 we recommend using the NEMA IQ phantom to calculate the necessary 4i8s 5.2 5.1 4.7 3.8 2.3 parameters. The NEMA IQ phantom is 4i24s 7.8 7.7 7.4 6.8 6.0 available as part of the optional NEMA UltraHD•PET 2i21s 7.9 7.9 7.6 6.9 6.2 Self-Test kit, but Siemens sales organi- zations may be able to provide alterna- 3i21s 8.1 8.0 7.7 7.1 6.3 tives for acquiring a phantom. 4i21s 8.0 8.0 7.7 7.0 6.2 1 Table 1: EQ•PET parameters computed with a 9.7:1 NEMA IQ phantom acquired on a Biograph mCT Flow and reconstructed with 3.4 x 3.4 x 2.0 mm voxels. The values presented align these reconstructions with the EANM/EARL guidelines pub- lished in 2015. Data courtesy of University of Iowa, IA, USA. Imaging Life | Issue 10 | www.siemens.com/imaginglife 73 Customer Care 2a SUV Parameters Alternatively, instead of performing individual phantom calibration scans for EQ•PET, users can collaborate, shar- ing EQ•PET parameters between sites that operate Units similar technology. For example, Table 1 lists the EQ•PET parameters able to normalize a set of common PET Color LUT reconstruction protocols on the Biograph mCT Flow™* with the current EANM and EARL specifications. CT Color LUT (2a-b) Set the Normalization Parameter PET Presets Once the EQ•PET parameter is calculated, the user en- ters the value into the EQ Filter field in syngo®.via** MM 300 40 Oncology, which is accessible via the SUV Parameters tab. CT Presets (3) Visualize Generated SUVs Home Windowing Visualize generated SUVs with EQ•PET by clicking on the display of the desired measure (e.g., Max.eq, Peak.eq, etc.). This feature is found in the tool configuration dialogue. SUV Parameters ? x (4) Use of EQ•PET in syngo.via Series Description HD After an EQ•PET parameter is entered for a given scan- Series Date/Time 28/07/2006 13:02:01 ner and reconstruction protocol, syngo.via software will automatically apply the appropriate parameter to all sub- Height cm Dose 421.8 MBq sequent datasets generated using the same protocol. Weight 55.39 kg Isotope F-18 EQ•PET parameters can be stored for multiple protocols. Sex Male Half-Life 109.77 Minutes 2b Injection Date 28/07/2006 EQ Filter 5 mm Injection Time 11:33:57 Further Information: Download the EQ•PET white paper OK Reset Cance from MIU 360’s growth resource page siemens.com/miu360 PET/SPECT Segmentation Properties ? X Display the following evaluations on PET/SPECT data: Max (Maximum) Max.eq (Maximum Equivalent) *Biograph mCT Flow is not commercially available in all countries. Peak (Highest Average 1cm3 Sphere) Due to regulatory reasons its future availability cannot be Peak.eq (Highest Average 1cm3 Sphere Equivalent) guaranteed. Please contact your local Siemens organization 3 Mean (Average) for further details. ** Mean.eq (Average Equivalent) syngo.via can be used as a standalone device or together with a variety of syngo.via-based software options, which are medical SD (Standard Deviation) devices in their own right. syngo.via and the syngo.via-based soft sD.eq (Standard Deviation Equivalent) ware options are not commercially available in all countries. Due Min (Minimum) to regulatory reasons its future availability cannot be guaranteed. Please contact your local Siemens organization for further details. Volume Thresh (Threshold of VOI Max) OK Cancel 74 Imaging Life | Issue 10 | www.siemens.com/imaginglife