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MI Neuro Cortical Analysis Centiloid Score

MI Neuro Cortical Analysis Centiloid Score

This job aid contains information about Neuro Cortical Analysis Centiloid Score, such as background, workflows and additional information.
 
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SIEMENS Healthineers MI Neuro Cortical Analysis Centiloid Score Job Aid Template Effective Date: 10 Aug 2021 | HILS 2223 Job Aid Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG I © Siemens Healthineers, 2024 Disclaimer SIEMENS Healthineers syngo.via O Scanner AI-Rad Companion V syngo.via Syngo Carbon View&GO Space Please keep in mind that the user interface may differ slightly from what is shown in this Job Aid. The actual usage of the tool may differ slightly on the different host systems, for example on syngo.via, Syngo Carbon Space, syngo.via View&GO, AI-Rad Companion or on the scanner. However, the intended purpose of the tool is the same. The tool functionality defined in this Job Aid is applicable to any of the Siemens Healthineers products in which you find this tool. 2 Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 MI Neuro Cortical Analysis Centiloid Score SIEMENS Healthineers Table of Contents Tau_Abnormal 005630 AVD S Scale: 0.4 FoV: 30.5x26.9cm MR: W 2721 L 1360.5 PET: W 8649.4 L 4324.7 Centiloid Score Background 4 005630 pet1 MI Neuro Cortical Analysis Workflow 1 5 MI Neuro Cortical Analysis Workflow 2 6 MI Neuro Cortical Analysis list of ROIs 7 Centiloid Score supported Tracers & Normalization regions 8 P Centiloid Score supported combination 9 Centiloid Score unsupported combination 10 Centiloid Score Copy and Export results 11 Study information 12 MIR:01-Jan-2012 11:06:15 Sagittal PET:01-Jan-2012 16:55:10 Slice 36/91 3 Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 Centiloid Score - Background SIEMENS Healthineers • The Centiloid approach describes a standard method of analyzing SUVR PIB 11C-Pittsburgh compound ( 11C-PiB) PET data. It provides a method for scaling of any non-standard method of 11C-PiB NAV4694 imaging. The method also scales image data from other Amyloid SUVR radiotracers to a uniform scale. Florbetapir • The Centiloid (CL) method, as proposed by W. Klunk et al., is OHHANS Florbetaben utilized to enable the comparison of Amyloid-PET data that has been acquired using various tracers or processed by different Flutemetamol methods. SUVR • The Centiloid method standardizes quantitative Amyloid imaging Tracer Ref Region Scenium CL Equation R2 (a) measures to a universal unit: The Centiloid score. FBP WC 173.26 x tracer SUVr -174.63 0.968 • The Centiloid score is calculated based on the tracer associated FBB WC 181.31 x tracer SUVr -175.90 0.981 with the composite region and the normalization region. FLUT WC 121.20 x tracer SUVr -117.24 0.968 • The Centiloid score allows data obtained at different sites to be Pons 250.73 x tracer SUVr -126.84 0.959 compared even with different tracers. It provides diagnostic and a: GAAIN vs. Scenium Centiloids; WC: whole cerebellum; CC: cerebellar cortex; FBP: florbetapir; FBB: prognostic thresholds in clinical practice and research. florbetaben; FLUT: flutemetamol, 4 *W. Klunk et al., “The Centiloid Project: Standardizing quantitative Amyloid Effective Date: 14 Aug 2024 | QR700011688 plaque estimation by PET”, Alzheimer’s & Dementia, 2015. Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 MI Neuro Cortical Analysis – Workflow 1 SIEMENS Healthineers MI Genera Data Selection All Data Basic Dynamic Static - Display Time MI Neuro WB - Dual Planar Volume Intensity Gated Stripe Subtraction • Launch the workflow directly from the Functional Fused Axial 3 ... Ax Yoligne syngo.via browser, or from the Open Apps Fused 2x3 Cardiac AC Cardiac + Movie NAC AC - NAC MI Neuro Striatal Workflow Selection × tool within MI General. Compare Analysis MI Organ Processing • Based on information found in the DICOM OpenApps X tag Radiopharmaceutical (0018,0031) Digital Marketplace syngo MBF Which type of study is being performed? either the Amyloid or the Tau workflow Amyloid (for assessment of amyloid plaques) will be launched. Without proper O Tau (for assessment of neurofibrillary tangles) information, a selection dialog pops up. Favorite Tools X MI Neuro DB Comparison Ares Reset OpenApps Contr ... Windowi ... • Please note: To learn about the full LayBut FAST 1:2 Note : The system will attempt to determine the type of study automatically based on the Custom Radiopharmaceutical (0018,0031). If the Radiopharmaceutical is set correctly at the scanner, handling of the tool, please watch the V. this dialog will not be shown. Automatic Hide Cardiac Registrat ... Graphics Mask MI Neuro e-learning on Cortical Analysis MI Neuro Cortical Analysis Hide Lines Radial Ranges Cortical Analysis. It is also known as E 4DM OK Exit Parallel Reset VOI Sphere Ranges Layout Scenium Ratio Analysis. Cardise Planes Corridor4DM Snapshot Visual FAST Alignment Ranges Cedars-Sinai Cardiac Suite 5 Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 MI Neuro Cortical Analysis – Workflow 2 SIEMENS Healthineers 1 1. The same familiar workflow begins MI Neuro Cortical Amyloid Fª18"[^18"Fluorine] AV-45 . Alzheimer's disease (arryloid) Scale: 0.61 FoV: 22.3x18.2cm . Alrhein - Alzheimer's disease (permyold) Scale: 0.61 FoV: 22.8x18.2cm . Alzheit Scale: 0.51 FOV: 23.1x18.2cm PET: W 22170 1. 13516.7 O-/- -- TW 22170 L Fusion to Template PET: W 22170 L 13616.7 O -/- -- with fusing patient data to the 201011222 201011222 201011222 Analysis 2 Amyloid template. Color Maps PET 2. The Analysis step provides a Normalization Region Cerebellum (forbetapir) . Show ............ .......... .............. selection list for the Normalization Regions of Interest Key Images Amyloid Plaque (florbetapir) Name Side Mean Max Region. Anten 17292 0 20244 9 Cereb B 8023.3 18527.9 Front 15012 0 20417 4 3 Panet 14289 4 18316.3 Poste 15868.8 17218 6 Precu 16885.8 18202 8 2.10 Axial Coronal Sagittal 15578 4 20606 6 PET. Slice 42/91 PET:-/ Slice 58/109 PET:-/ Slice 48/91 3. The Analysis step provides a Temp B Normalization region: Cerebellum (florbetapir) Composite Region: Amyloid Plaque (florbetapir) selection list for the Composite ROI Ratio Mean ((-)) Maximum ((-)) Anterior cingulate gyrus (florbetapir) 2.16 17292.0 20244 9 Frontal lobe (florbetapir) 1.87 15012.0 20417.4 Regions. Parietal lobe (forbetapir) 1.78 14289.4 18316.3 Posterior cingulate gyrus (florbetapir) 1.98 15868.8 17218.6 Precuneus (fiorbetapir) 2.10 16885.8 18202.8 Temporal lobe (florbetapir) 1.94 15578:4 20606.6 Average 1.97 Values displayed are (-) 4. The analysis step calculates SUVr 4 values for the ROIs within composite regions. It also Copy Export Results determines the ratio of these regions to the chosen normalization region. 6 Data courtesy of Rome Imaging Center, Rome, Georgia, USA. Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 MI Neuro Cortical Analysis – List of ROIs SIEMENS Healthineers 1 Florbetaben RO Anterior cingulate gyrus (florbetaben) Frontal lobe (florbetaben) Occipital (florbetaben) Parietal lobe (florbetaben) The list of ROIs under the standard Posterior cingulate gyrus (florbetaben) Composite regions are: Temporal lobe (florbetaben) 1. Florbetaben 2. Florbetapir 2 Florbetapir 3 Flutemetamol 3. Flutemetamol ROI ROI Anterior cingulate gyrus (florbetapir) Anterior cingulate gyrus (flutemetamol) Frontal lobe (florbetapir) Frontal lobe (flutemetamol) Parietal lobe (florbetapir) Parietal lobe (flutemetamol) Posterior cingulate gyrus (florbetapir) Posterior cingulate gyrus (flutemetamol) Precuneus (florbetapir) Precuneus (flutemetamol) Temporal lobe (florbetapir) Temporal lobe (flutemetamol) 7 Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 Centiloid Score supported Tracers and SIEMENS Healthineers Normalization regions Composite Region Normalization Region H. Amyloid Plaque (florbetapir) Cerebellum (florbetapir) Supported Tracers & Normalization Amyloid Plaque (florbetaben) Whole Cerebellum (florbetaben) regions for calculation of Centiloid Score: Cerebellar Cortex (florbetaben) The Centiloid Score will only be calculated Amyloid Plaque (flutemetamol) Pons (flutemetamol) for the supported combinations of the normalization region and composite Whole Cerebellum (florbetapen) region. 8 Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 Centiloid Score supported combination SIEMENS Healthineers View Annotations Tools Help abc 1. To calculate the Centiloid, MI Genera MI Neuro Cortical Analysis CT 3.00 Hr40 A2 AC PET Neuro 2.00 AC Gaussian 4.0 ax 900s F-18 Florbetapir F^18^ select a supported Trinion_EP_Neuro_02_Amyloid Biograph A Scale: 0.5 FoV: 27.1x22.2cm Trinion_EP_Neuro_02_Amyloid Biograph S Scale: 0.5 FoV: 27.2x22.2cm Trinion_EP_Neuro_02_Amyloid Biograph Scale: 0.5 Fov: 8x22.2cm CT: W 80 L 40 F 001D 01-Jan-2024 CT: W 30 L 40 F 001D 01-Jan-2024 V 80 L 40 Scores get updated when a PET: W 8567.1 L 5449.4 +/- PET: W 8567.1 L. 5449.4 -/- PET: W 8567. 1 5449.4 F18 Florbetapir 9.75 mCi (360 MBq) F18 Florbetapir 9.75 mCi (360 MBq) combination of a supported normalization region is selected. normalization region and composite region. 1 Transparency CT 2. Appropriate Centiloid PET Series Normalization Region calculation equation will be Cerebellum (florbetapir) y Show Regions of Interest Key Images used based on the tracer and Amyloid Plaque (florbetapir) CT:27-Jun-26 3 9 13:40:29 PET:27-Jun-201 13:41:40 P Slic 1 In-2019 13:40:29 un-2019 13:41:40 Coronal CT:27-Jun-2019 13:40 29 Slice 66/109 PET:27-Jun-2019 13:4140 Sagittal Slice 52/91 Anteri ... B 6240.9 7974.5 normalization region. Each 1.41 Findings Cereb B 4436.2 9544.1 Normalization region: Cerebellum (florbetapir) Composite Region: Amyloid Plaque (florbetapir) Front .. B 6431.6 8382.6 1.45 Pariet. B 5756.4 8152.6 1.30 1.47 RO Ratio Mean (Bq/ml) Composite region has a single Poste ... B 6501.9 7707.3 Scores get updated when a Precu B 7203.2 8710.2 1.62 Temp 1.45 Anterior cingulate gyrus (florbetapir) 1.41 6240.9 B 6415.0 8706.4 Frontal lobe (florbetapir) 1.45 6431.6 Centiloid Score value. Parietal lobe (florbetapir) 5756.4 supported normalization 1.30 Posterior cingulate gyrus (florbetapir) 1.47 6501.9 Dranunaus /florhatanir CO 7203.2 region is selected. Printing Temporal lobe (florbetapir) 1.45 6415.0 Average 1.45 Centiloid score 75.6 Values displayed are Bq/ml 2 Copy Export Results Average and Centiloid Score displayed for a given composite region. 9 Data courtesy of Rome Imaging Center, Rome, Georgia, USA. Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 Centiloid Score unsupported combination SIEMENS Healthineers View Annotations Tools Help + MI Gene abc MI Neuro Cortical Analysis CT 3.00 Hr40 A2 AC PET Neuro 2.00 AC Gaussian 4.0 ax 900s F-18 Florbetapir F^18^ Scores do not get updated Biograph A Scale: 0.5 Fov: 27.1x22.2cm Trinion_EP_Neuro_02_Amyloid Biograph S Scale: 0.5 Fov: 27.2x22.2cm |Trinion_EP_Neuro_02_Amyloid Biograph S Scale: 0.5 Fov: 28x22.2cm H. CT: W 80 L 40 F 001D 01-Jan-2024 CT: W 30 L 40 F 001D 01-Jan-2024 CT: QV 80 L 40 PET: W 8567.1 L 5449.4 +/- PET: W 8567.1 1. 5449.4 -/- PET: W 8567.1L 5449.4 when an unsupported F18 Florbetapir 9.75 mCi (360 MBq) F18 Florbetapir 9.75 mCi (360 MBq) 1. If an unsupported combination normalization region is of a normalization region and selected. composite region is selected, Transparency 1 the score will not be calculated. CT PET Series Normalization Region 2. Centiloid Score does not get Cerebellum + Vermis (AAL) v Show Regions of Interest Key Images 1 displayed for custom ROIs. Amyloid Plaque (florbetaben) :27-Jun-26 9 13:40:29 WICCITT ET:27-Jun-201 13:41:40 P TYCITIC Slice 39191 PET.25 0-2019 13:40:29 Coronal CT:27-Jun-2019 13:40 2. Sagittal IVICA Anteri. B 5726.9 7821.9 Findings Cerer B 3320.2 6109.3 0.92 Normalization region: Cerebellum + Vermis (AAL) Composite Region: Amyloid Plaque (florbetapir) B 5821.5 8847.4 1.61 Occipi ... B 5184.0 8760.4 1.43 Pariet. B 5730.3 8607.1 1.58 RO Ratio Mean (Bq/ml) Composite Region: Custom ROI Poste B 6821.5 8737.3 1.89 Temp Temp. B 5629.7 8492.6 1.56 Anterior cingulate gyrus (florbetapir) 1.73 6240.9 Frontal lobe (florbetapir) 1.78 6431.6 Scores do not get updated Parietal lobe (florbetapir) 1.59 5756.4 Posterior cingulate gyrus (florbetapir) 1.80 6501.9 Precuneus (florbetapir) 1.99 7203.2 when an unsupported Printing Temporal lobe (florbetapir) 6415.0 normalization region or Centiloid score custom ROI is selected. The list of ROIs shown in this summary does not match the current ROI selection. To update use Composite Region Dropdown. Values displayed are Bq/ml 2 Centiloid score not supported for the selected combination of composite and normalization region. Copy Export Results Centiloid Score unavailable for the selected composite and/or normalization region combination. 10 Data courtesy of Rome Imaging Center, Rome, Georgia, USA. Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 Copy and Export results SIEMENS Healthineers Normalization region: Cerebellum (florbetapir) Composite Region: Amyloid Plaque (florbetapir) H. ROI Ratio Mean ((-)) Maximum ((-)) Anterior cingulate gyrus (florbetapir) 2.16 17292 20244.9 Copy and Export Frontal lobe (florbetapir) 1.87 15012 20417.4 Parietal lobe (florbetapir) 1.78 14289.4 18316.3 • A comma-separated-variable Posterior cingulate gyrus (florbetapir) 1.98 15868.8 17218.6 (CSV) file of the results can be Precuneus (florbetapir) 2.1 16885.8 18202.8 exported using the Export Results Temporal lobe (florbetapir) 1.94 15578.4 20606.6 button. Average 1.97 • Centiloid score Copy and Export options include 25.2 the Centiloid score and average Normalization region: Cerebelum (florbetapir) Composite Region: Amyloid Plaque (florbetapir) values. ROI Ratio Mean ((-)) Maximum ((-)) Anterior cingulate gyrus (florbetapir) 2.16 17292.0 20244 9 Frontal lobe (florbetapir) 1 87 15012.0 20417.4 Parietal lobe (forbetapir) 1.78 14289 18316.3 Posterior cingulate gyrus (florbetapir) 1.98 15868.8 17218.6 Precuneus (fiorbetapir) 2.10 16885.8 18202.8 Temporal lobe (florbetapir) 1.94 15578:4 20606.6 Average 1.97 Values displayed are (-) Copy Export Results 11 Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 High levels of cortical Amyloid deposition delineated on SIEMENS Healthineers Amyloid brain PET study with high matrix reconstruction 800 • Amyloid PET/CT study in patient with suspected cognitive decline. • Visual evaluation of Amyloid PET images reconstructed with a high matrix shows increased Axial cortical Amyloid burden, especially in the precuneus, frontal, and lateral temporal regions. • Cortico-cerebellar SUVr of 1.43 generated from syngo.MI Neuro Cortical Analysis suggests moderately high levels of cortical Amyloid. Sagittal Biograph Trinion TM EP PET/CT PET (18-cm aFOV) Scan acquisition: Total scan time: 15 minutes Image reconstruction: 512 x 512 matrix, PSF+TOF, 4i6s, Gaussian filter 4. Coronal Injected dose: 18F Amyloid tracer injection 9.75 mCi (360 MBq) (5.4 MBq/kg). PET Patient details: 67 kg (147 lb), 157 cm (5’ 2”), 28 BMI. CT (64 slices) Scan parameters: 80 kV/200 ref mAs. 12 Data courtesy of Rome Imaging Center, Rome, Georgia, USA. Effective Date: 14 Aug 2024 | QR700011688 Biograph Trinion is not commercially available in all countries. Future availability cannot be guaranteed. Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 High cortico-cerebellar SUVr values correlate with SIEMENS Healthineers visibly high levels of cortical Amyloid deposition S S R LR Normalization region: Cerebellum Composite Region: Amyloid Plaque ROI Ratio Mean (body weight SUVs) Maximum (body weight SUVs) Anterior cingulate gyrus 1.37 1.57 1,98 Frontal lobe 1.42 1.63 2.14 Parietal lobe 1.29 1.48 2.10 Posterior cingulate gyrus 1.46 1.68 1.98 Precuneus 1.63 1.88 2.25 Temporal lobe 1.42 1.63 2.23 Average 1.43 13 Data courtesy of Rome Imaging Center, Rome, Georgia, USA. Effective Date: 14 Aug 2024 | QR700011688 Biograph Trinion TM is not commercially available in all countries. Future availability cannot be guaranteed. Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 High levels of cortical Amyloid deposition delineated on SIEMENS Healthineers Amyloid brain PET study with high matrix reconstruction PET MIP AVI 14 Data courtesy of Rome Imaging Center, Rome, Georgia, USA. Effective Date: 14 Aug 2024 | QR700011688 Biograph Trinion TM is not commercially available in all countries. Future availability cannot be guaranteed. Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024 SIEMENS Healthineers Please note this learning material is for training purposes only. For the proper use of the software or hardware, please always use the Operator Manual or Instructions for Use (hereinafter collectively “Operator Manual”) issued by Siemens Healthineers. This material is to be used as training material only and shall by no means substitute the Operator Manual. Any material used in this training will not be updated on a regular basis and does not necessarily reflect the latest version of the software and hardware available at the time of the training. The Operator Manual shall be used as your main reference, in particular for relevant safety information like warnings and cautions. Please note: Some functions shown in this material are optional and might not be part of your system. Certain products, product related claims or functionalities (hereinafter collectively “Functionality”) may not (yet) be commercially available in your country. Due to regulatory requirements, the future availability of said Functionalities in any specific country is not guaranteed. Please contact your local Siemens Healthineers sales representative for the most current information. The reproduction, transmission or distribution of this training or its contents is not permitted without express written authority. Offenders will be liable for damages. All names and data of patients, parameters and configuration dependent designations are fictional and examples only. All rights, including rights created by patent grant or registration of a utility model or design, are reserved. Siemens Healthineers HQ I Siemens Healthineers AG Siemensstr. 3 91301 Forchheim Germany Phone: +49 9191 18-0 siemens-healthineers.com Author | Department 15 Effective Date: 14 Aug 2024 | QR700011688 Unrestricted I Published by Siemens Healthineers AG | © Siemens Healthineers AG, 2024

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