syngo.via Frontier Cardiac Functional Analysis

In this research application, we are able to perform a quantitative statistical analysis of 2D polar map with the related American Heart Association segments where we can draw region of interest which also measures the underlying 3D data. This relates in particular to dynamic myocardial perfusion analysis studies. This research application is also suitable for measuring the extracellular volume. It's suitable for both single energy data and for dual energy data. To open the case, please right click on the selected patient, select open with and then select CT cardiac function analysis frontier. This data set is sent to a single via frontier. Then we will be able to select the research application that we want to have. Here we have the list with research applications that can be selected. We can select cardiac functional analysis for example. It is always good to check if you have the latest version of this research application. Research applications are improved locally every now and then and this is version 24. We also have version 23 available over here, but we will select this one. Behind the information button you can find references, but also the manual for this research application. It's always useful to check the manual if there have been changes in the research application. Once we click on the tile, the research application starts and prepares to show us the images. Once a research application is opened, a screen appears where we can mention which different data roles should be assigned to the different series we have. Here is a drop down menu where you can select what kind of a series. The system automatically detects it already. This is the VPC Act average data set. But if the recognition is not done automatically, you can simply select the possibilities here. If you can change the series names, it might be nice to change the names accordingly to one of these tags. The system will automatically start and find the data rolls for the different series. This is the average. We leave it like this and simply press OK to start the analysis. I selected the myocardium with the EPICARDIUM and the endocardium lines and if the system does not work properly, most of the time it does because it is very well programmed, then we can select this ourselves. We need to drop down this menu and press edit contours. Afterwards you will find a little red area over here or we can select the blue area. You see that we simply can draw a Alongside myocardium. Now we connect to the blue line again and DoubleClick. And then you see that the line is updated a little bit. To switch off this functionality, press on this button again. We can also initialize the segmentation that the system did manually. It's useful when the system does not work properly. Furthermore, we can edit the base plane. In the base plane, we can scroll this a little bit up because everything below the base plane will be taken into account in the measurements. It was a little bit low. We have here a button for the different lanes that we have. Or we even have a button for the orientation. We can have a mitral valve orientation or an aortic valve presentation over here. When we window a little bit we can see this all a bit better over here, and the aorta valve is quite nicely presented. We go over to the analysis tab. Here we will do the left ventricle analysis. We have over here the first pass enhancement. I will change the view again back to the two Chamber view. The four chamber view and the longer axis that we have over here. In the meantime, the system already did some measurements. That can be very useful. And with color coding, the system offers this functionality over here, the first pass enhancement in the myocardium. With this slider bar that we can find here, we can set the sensitivity. It's now automatically set to 83, which gives us a nice view of this first pass enhancement. The next step that we can do with this research application is to analyze the polar maps. Once I click on the button, the compute polar maps will be calculated and will be presented to us. The polar maps are presented here. We can double click this segment to make this a little bit bigger and you see quite clearly the American Heart Association segments with the different measurements. We can select the measurement that we want to have. For instance, the VCT blood volume, maximum enhancement total and a blood flow for the endocardium. Here we can measure in those areas. You see qualitatively in color coding the values and you can also see some values when you hover over it with the mouse. To make this a little bit more precise, we can do a circular region of interest measurement. And for instance, in this area we can measure this region of interest and get the numbers in milliliter per 100 milliliter tissue per minute. As a comparison, we can take a segment at 10 which is apparently not affected as a reference to compare those values. Later this data will be sent out so we can analyze this in a different way. The region of interest is still active, so we deactivate it. I double click again. We can do some polar map navigation. It is assigned to the endocardium. You can see it over here. The endocardium or epicardium measurements are set over here, so we can select those possibilities. What we can also do is put polar maps here and integrate them in the areas that we find over here. I will switch off some functionalities at this point. And then we get the grayscale, for instance the endocardium mask over here. You see the blood flow color map. It's quite clearly visible what we can do with this. We like to send this out. Because when we alone look at this data, it doesn't make so much sense. Therefore we have different data exchange possibilities. We can also load a data set in here. And even load a region of interest. We can send out those data as an STL file. I'll show this to you. We store this on the desktop. We can export the different regions of interest. And we can also export this according to the AHA results over here. Let's say we export the region of interest from the polar maps also to the desktop. This research application is also available for the analysis of the extracellular volume. For that you need to load different data which are not currently available in this research application. You would have to leave select the data and select the CV analysis again. We will now go to the desktop of Syngo via. Here we have a cardiac functional folder over here. Let's see what was given to us. We have the MPI which might be the STL file. But when we look at the properties, we clearly see that it is a STL file. We can use this for 3D printers. We have here the AA mapping in a comma separated value. When I open it in the preview lane, you can see the note with the CSV values here, where we have all the measurements available with the numbering. Afterwards we can easily enter this into an Excel sheet to find out the different measurements. In a comma separated value file we have the different regions of interest which we can do further analysis on. Of course, this research application has also the help functionality, a reset button. And the possibility to take screenshots of it, which we also can send to the desktop for later analysis. And with that, I thank you very much for your attention.

1/1/2013 1/1/1946 1/1/1964 1/1/1947 1/1/1951 1/1/1977 1/1/1974 1/1/1971 1/1/1956 1/1/1952 26 1/1/1800 1/1/1918 504 505 506 507 508 975 5.0.0 2.0.4 1.0.7 1.5.7 204 2.0.1 122 22 120 5.0. 1.2.5 121 2593494786528 095206.8 2593494770032 2593494775200 2593494769536 2593494770480 83 40% 13 14 17 15 10 (0.1/0.3) (0.0/0.0) (0.0/0.1) 11 (144.7/40.3) (51.8/25.7) (131.7/29.6) 150.0 (61.1/22.7) (168.9/28.6) (77.7/21.3) (69.1/23.3) (158.3/42.4) (170.7/28.4) 0.1/0.3 0.0 158.3/42.4) (0.0/0.0 (64.3/22.7) 100.0 16 (178.4/35.7) 100.1 25.0 -200.0 200. (151.6/23.2) 3/10/2021 20140701 170925.546000 0.29296875 80 .38,29.29 88 Cardiac Functional Analysis syngo.via Frontier* *syngo.via Frontier & research applications are not intended for clinical use and are for research purposes only. SIEMENS Healthineers Patient Browser Read (35) *FRO* Results (31 results, 2:55:33 PM) Series Workflow Status Workflow Desc .. Patient Name Date of Birth Patient ID Modality Study Date and ... FRO_3DPrinting_Heart CT, SEG 2/4/2014 3:5 .. FRO_AspectScore_2 CT FRO BestContrast_Male 1ed6b9d182 7/17/2013 8 :... FRO_BoneSubtraction_1 9/3/2010 9:3 ... c69142ac66 FRO_Cardiac_Plaque_DE b5f2f55519 1/11/2013 2 :.. FRO_CardiacRiskAnalysis_2 8ca38b5d9a 11/11/2014 3 ... CT, OT, SEG, SR FRO CineRender_CAROTIS_DUENN FRO_CineRender_FL_AAA f8309b4d18 CT, OT FRO_CineRender_HeadNeck_1 12/28/2007 8 ... Instances FRO_DIEP_FLAP_1 7079c72c21 11/2/2015 3 :... FRO_DualEnergy_Kidney_Carcinoma C566614221 CT, SEG, SR 1/30/2007 4 :... FRO_DualEnergy_Lung 9/11/2007 11 ... FRO_FlowVisualization_2 2/2/2013 7:4 ... FRO_Iron 8/27/2017 11 ... FRO_SyntheticCT_1 CT, MR, SEG CT, SR 9/14/2015 12 ... FRO_Unfolding_Pelvis_1 The selected data opened as read-only 2:55 PM FO 94 947239fd3e fc33d6c641 10/23/2013 1 ... 2/4/2014 3:5 ... 12/24/2012 6 ... 9/3/2015 7:5 ... 65daec0387 10/3/2008 9 :... 6ed6df2b8b FRO_BestContrast_Male 10/25/2012 8 ... X Q Series D + SR 6/9/2022 4: 7/1/2014 5: VPCT BVM #1 26.25 MB FRO_Cardiac_Plaque_LAD VPCT KTM #1 FRO CardicaFunction 12/28/2007 8 .. Browse More Filters Print Open with DICOM Send to Delete Archive Results (10 results, 6:34:30 PM) Workflow Description Series Number Series Description Size Report Data 89.15 KB FRO_AspectScore_1 VPCT AVG #1 VPCT BF #1 e53021e6d4 ae6114cdfd bd9e54674f FRO_CineRender_Cardiac10Stents d83ab8a5e0 Workflows of the selected studies are cancelled 6:34 PM Open Oper Open with View as Read-Only with Batch Open Assign Workflow Group Studies Batch Assign Workflow Cancel Workflow Search Patient with DICOM Q/R Ctrl+Shift+S Send to Archive ber Add to Demo List Remove from Demo List Set Mark state Set Delete Protection state Set Archive state Remove Correction state Correct Cut Paste Del FRO_CardicaFunction Favorites CT CaScoring CT Dental MM Radiomics Frontier MM Reading Suggested Open with DICOM CT Colon CT Coronary CT Coronary + Ca CT Coronary Plaque Analysis Frontier CT DE + Vascular More CT Dual Energy CT Dynamic Angio DICOM CT Myocardial Perfusion CT Myocardium At Risk Frontier CT Neuro DSA CT Neuro Perfusion CT Neurovascular CT Pelvic DSA Frontier CT cFFR Frontier CT Chest Pain CT Cardiac Function CT Cardiac Functional Analysis Frontier CT Cardiac Planning CT Cardiac Risk Assessment Fikntier Opening selected data using workflow CT Cardiac Functional Analysis Frontier ... O bd9e54674f Loading ... Starting ... Not for clinical use Select a prototype All prototypes are not intended for clinical use Frontier ID: 000001 Go to syngo.via Frontier Prototype Go to syngo.via Frontier Support and Discussion Forum Recently Used Cardiac Functional Analysis Cinematic Rendering Coronary Plaque Analysis Siemens Healthineers CT Creates photorealistic 3D view of CT and MR datasets from single and dual energy CTA Expiration date: Dec. 31, 2021 Expiration date: June 30, 2021 3D Printing Best Contrast NEW Load, edit and create segmentation objects for 3D Emphasises the contrast Cardiac Risk Assessment This prototype is used to assess Non-Contrast CT Data for abdominal fat and pericardial fat CT Pneumonia Analysis CT Skull Unfolding 4.3.1 ext consistent with pneumonia. Expiration date: Sept. 30, 2021 Abdomen/Heart Fat Analysis on cardiac risk by quantifying quantification of abnormalitites Create and manage patient- Store consistent with pneumonia SIEMENS . Research Application Starting ... MM Research Frontier Acquisition Time Cardiac Phase Data Role VPCT_AVG ECV Analysis VPCT_BLOODFLOW Left Ventricle Analysis VPCT_BLOODVOLUME_MAX_ENHANCEMENT Data Exchange VPCT_BLOODVOLUME_MDC VPCT_KTM You may change the assigned datarole with the context menu of the corresponding volume OK ID CTA LE CTA_REST CTA STRESS ECV PASE ECV_LATE IGNORE ECV_CTA DEPEV VPCT AVG #1 095206.8 Grayscale SOMATOM Force AR RPH SOMATOM Fort 00-mm VPCT HLA VPCT AVG 90 mm AVG VPC search Frontier Functional Analysis AH RHP FR C 182 b C 142 W 181 C 206 C 206 b Polarmap navigation Ep VPCT AVG FPE Volume: 3.56 ml / 3.57 % Myocard Volume: 99.75 ml FRO_CardicaFunc THLA Total/Mid W 181 FR VPCT BF Total VPCT KTM Total Mean = 66.7 Mean = 149.6 Mean = 136.4 Mean = 0.0 VPCT BV MAX Enhancement Total ml/100ml FPE_Mask ml/100ml/min VPCT BF Endocardiac E 10 Mean/SD: 69.5/23.3Mean = 66.7 ROI 2 Min/Max: 0.0/0.0 Mean/SD: 166.3/19Mean = 140.5 W 181 FRO_CardicaFunction Endo Epi Total/Mid Endo W 181 FRO_CardicaFun STL Browse For Folder Select Result Folder Desktop Libraries Network Make New Folder Cance FRO_CardicaFun This PC Downloads Pictures Documents Music Type here to search syngo 10.1.1.52 3:09 PM Cardiac Functional Analysis 2021-03-10_025811 Fille Home Share View P Search Cardiac Functional Analysis_2021-03-10_025811 Name Date modified Type 3/10/2021 3:08 PM 3D Object 1,023 KB CSV File 6 KB 3 KB Videos Cardiac Functional ... 1 item selected 0.99 MB FRO_Cardicafunction Edit with Paint 3D Scan with Windows Defender ... 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Cancel Date created 3 item Type: CSV File Date modified: 3/10/2021 3:08 PM Hidden items Hide selected Options items No preview available. 3 items Patient's Name: Series Date: series Time: Chamber detection on series: Image size [voxel x voxel x Pixel size [mm x mm]: slice increment [mm]: 2 Polar map configuration: FPE Mask: (start:0 end:0.98) VPCT KTM Total: (start:0 end:1) VPCT BV MAX Enhancement Total: (start:0 end:1) VPCT BV MDC Total: (start:0 end:1) VPCT BF Endocardiac: (start:0 VPCT BV MAX Enhancement Endocardiac: (start:0 end:0.5) VPCT BV MDC Endocardiac: VPCT BF Epicardiac: (start:0.5 VPCT BV MDC Epicardiac: (start:0.5 end:1) Build:Aug 11 2020 15:33:26 1.0 chamber detection on series: VPCT AVG #1 Image size [voxel x voxel x voxel]: 512 x Pixel size [mm x mm]: 0.29296875 x VPCT BV MAX Enhancement Total: (start:0 VPCT BV MDC Total: (start:0 end:1) VPCT KTM Endocardiac: (start:0 end:0.5) VPCT BV MAX Enhancement Endocardiac: VPCT BV MDC Endocardiac: (start:0 end:0.5) VPCT KTM Epicardiac: (start:0.5 end:1) VPCT BV MDC Epicardiac: (start:0.5 end:1) Polarmap/AHA segment, avg 1, avg 2,avg 3,avg 2,std 3,std 4,std 5,std 6,std 7,std 8,std 9,std 10,std 11,std 12,std 13,std 14,std 15,std 16,std 17 VPCT BV MDC Total: (s VPCT BF VPCT KTM VPCT BV MDC 6,59. 55,86.45,73.79,65. 36,16855,6601 ,4239,95 041,43803,39504, 24302, 37434, 33345,19068,40.9 Series Time: Slice increment [mm]: 2 Size: 2.09 KB VPCT BF Total: (start:0 end:1) VPCT BV Total: (start:0 end:1) VPCT BF Endocardiac: (start:0 end:0.5) VPCT BF Epicardiac: (start:0.5 end:1) 1,0 VPCT BV MDC Epicardiac: (start:0.5 end:1) 9,std 10 ate 170925. 546000 AF T4 The user must ensure that the Frontier Research Applications and/or the results obtained by their utilization will be used for Research Use only. "Research Use" means the use of a software for research (particularly for basic research) where the software itself is not validated. Research Use does not include market and feasibility studies concerning the software as well as any clinical use of the software, namely its use for any patient- specific examination in connection with the preparation of a diagnosis or therapy planning. The use of a Frontier Research Application in connection with any system cleared as a medical device may affect the medical device clearing of said system. The user has to ensure that the application of any Frontier Research Applications is in accordance with applicable laws and regulations (e. g. ethic committee approval). Except as expressly set forth otherwise in this agreement, the Frontier Research Applications are provided "as is" without any warranty. 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