ACUSON Sequoia™ 3.5 VB30 UDFF Poster

Liver Health Guidance for Ultrasound Derived Fat Fraction (UDFF) Measurements siemens-healthineers.com/ultrasound Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD) is the most common chronic liver disease worldwide1. Ultrasound Derived Fat Fraction (UDFF) is an advanced tool for quantifying liver fat content in (%). UDFF and shear wave elastography (SWE) measurements of liver stiffness provide a comprehensive noninvasive assessment of MASLD. Based on the suggested scanning protocol outlined below, UDFF has demonstrated2: 4a 2 7 8 • Strong agreement with MRI Proton Density Fat 1 Fraction (MRI-PDFF) 3 4b • Strong diagnostic performance for assessing steatosis grades 6 5 • Excellent intraoperator repeatability • Good to excellent interoperator reproducibility Suggested scanning protocol for UDFF measurements in adults and children. Protocol Notes Fasting not mandatory Fast for at least 4 hours if measuring liver stiffness with UDFF Right intercostal space Supine position with arm at maximum abduction to maximize intercostal spacing and avoid ribs Best quality of B-mode image Minimize rib shadows and ensure good transducer contract Measurement box perpendicular Place box in liver parenchyma and avoid areas with large vessels, to transducer shadows, anatomic interfaces, or ribs. Upper edge of measurement box Position measurement box below the liver capsule and align the 1.5 to 2 cm below liver capsule indicator with the capsule. Breath hold Ask patient to suspend breath to minimize blurring during acquisition Median UDFF value of three to Acquire 3–5 valid measurements at the same site and report the five measurements median value. Invalid measurements are indicated by x.x. Note: The suggested protocol is based on the WFUMB guidance on liver fat quantification.1 Suggested interpretation of liver UDFF 1 WFUMB Guideline/Guidance on Liver Multiparametric Ultrasound: Part 1. measurements in adults and children.2,3,* Update to 2018 Guidelines on Liver Ultrasound Elastography; Ferraioli, Giovanna et al. Ultrasound in Medicine and Biology, Volume 50, Issue 8, 1071 - 1087 (2024), https://doi.org/10.1016/j.ultrasmedbio.2024.03.013 UDFF (%) Interpretation 2 Kubale, Reinhard, et al. "Ultrasound-Derived Fat Fraction for Hepatic ≤ 5% Rule out S ≥ 1 (minimal steatosis) Steatosis Assessment: Prospective Study of Agreement with MRI PDFF and Sources of Variability in a Heterogeneous Population." American Journal ≤ 10% Rule out S ≥ 2 (minimal to mild steatosis) of Roentgenology (2024). https://doi.org/10.2214/AJR.23.30775 3 Zalcman, Max, Richard A. Barth, and Erika Rubesova. "Real-time ≤ 15% Rule out S3 (mild to moderate steatosis) ultrasound-derived fat fraction in pediatric population: feasibility validation with MR-PDFF." Pediatric Radiology 53.12 (2023): 2466-2475. > 15% S ≥ 2 (moderate to severe steatosis) https://doi.org/10.1007/s00247-023-05752-0 > 20% S3 (severe steatosis) *Data on file. ‘S’ represents steatosis grade, defined as follows: S0 (PDFF ≤ 5%), S1 (5% < PDFF ≤ 15%), S2 (15% < PDFF ≤ 20%), and S3 (PDFF > 20%). Steatosis severity is categorized as minimal (S0), mild (S1), moderate (S2), and severe (S3). • UDFF exhibits bias toward slightly larger values versus MRI-PDFF. Larger differences between UDFF and PDFF occur at higher UDFF and MRI-PDFF values, with some outliers present at these levels. • Diagnostic performance indicates Area Under Receiver Operating Characteristic (AUROC ≥ 0.88). For more information, please visit siemens-healthineers.com/ultrasound or contact your local Siemens Healthineers sales representative. Siemens Healthineers Headquarters Siemens Healthineers AG Siemensstr. 3 91301 Forchheim, Germany Phone: +49 9191 180 siemens-healthineers.com Published by Siemens Healthineers AG · 15968 1024 online · ©Siemens Healthineers AG, 2024