Multiparametric PET AI: Manual Input Function (IF) Generation in TrueD Job Aid

Multiparametric PET AI: Manual Input Function (IF) Generation in TrueD Multiparametric PET AI Imaging There may be instances where a customer wants to enter input functions (IF) manually. The auto- mated function within the Multiparametric PET AI imaging workflow works well, but some cus- tomers may also decide to enter their own arterial blood samples for modeling. Before you start 1. Load the dynamic series’ in the TrueD task card 2. Select all data series’ and select Load New Transfer Edit View Image Orientation VRT Type Quantification Tools Reports Options Help TrueD Series List X Intervention Patient Name Patient ID Date of Birth 49 18.07.20-14:33:12-STD-1.3.12.2.11 ... 20-Jul-1943 Sex Patlak, Clifford M Viewing Valid Series Modality Study Description Study Date Series Description Series No. No. of Images Phase |C. PET^WholebodyDy ... 20-Jul-2018 AC CT WB RTD 101 Volume Rd PT PET^WholebodyDy ... 20-Jul-2018 PET WB Input Regio 7 PET^WholebodyDy ... 20-Jul-2018 PET WB Input Regio 7 PT PT PET^WholebodyDy ... 20-Jul-2018 PET WB Input Regio 7 Result PT PET^WholebodyDy ... 20-Jul-2018 PET WB Input Regio 7 3D PT PET^WholebodyDy ... 20-Jul-2018 PET WB Input Regio 7 PT PET^WholebodyDy ... 20-Jul-2018 PET WB Input Regio 7 7 PT PET^WholebodyDy ... 20-Jul-2018 PET WB Input Regio PET^WholebodyDy .... 20-Jul-2018 PET WB Input Regio ... 7 888888888 Automatic Re Invalid Series Modality Study Description Study Date Series Description Series No. No. of Images | Frame of Reference TrueD Merge when possible Show invalid series list Load New Append Replace Cancel Help Visualizati MIP Quantification Report 20- Jul-2018 14:57:01 Unrestricted | Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2022 SIEMENS Master Template Effective Date: 10 Aug 2021 | HILS 2224 Job Aid Effective Date: 31-Aug-2022 | HOOD05162003294128 Healthineers Job Aid | Multiparametric PET AI: Manual Input Function Generation in TrueD Effective Date: 31-Aug-2022 | HOOD05162003294128 To generate new input functions manually 1. Draw your Volume of Interest (VOI) in the desired location (e.g. left atrium) 2. Label the VOI if desired Volume Registration Visualization MIP Must hit enter 3D Quantification otherwise label or Toggle "Select Report edits not saved Report" to see "VOI Label" field below VOLID 3 VOI Details TrueD WolLabel Livar Key Images SIEMENS Unrestricted | Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2022 Master Template Effective Date 10 Aug 2021 | HILS 2224 Healthineers Page 2 of 6 Job Aid | Multiparametric PET AI: Manual Input Function Generation in TrueD Effective Date: 31-Aug-2022 | HOOD05162003294128 3. Copy the VOI across timeslices by selecting the Quantification task card and selecting the VOI to copy 4. Then select the Copy VOI across Timeslices icon 5. VOI’s can be adjusted on a timslice basis and saved (e.g. to correct for patient motion) VOS1C 01-Jan-1933 09 Dec-2016 Aug 27048 Dar 300 SP A153 TA 2007 291 090000 NEP genovel VOS1C CO! PUSED MEIN Start Time 2258 All Segments A x SIEMENS Unrestricted | Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2022 Master Template Effective Date 10 Aug 2021 | HILS 2224 Healthineers Page 3 of 6 Job Aid | Multiparametric PET AI: Manual Input Function Generation in TrueD Effective Date: 31-Aug-2022 | HOOD05162003294128 6. To view the Time Activity Curves (TAC), choose VOI Analysis under the Quantification tab TrueD: VOI Analysis Presets Default Quality Control TAC Tranditta Conditional Formolting Show on Graph All VOIS Time Unit second Timne Slice LinkSet Metrics Plot On Graph Time Slice 1 Time Slice 2 Time Slice 3 Time Slice 4 Time Slice S Time Slice 6 Tim VOL Time (second) 5.00 15.00 25.00 35.00 35.00 35.00 Min (BqimL) 455 39343 81909 66565 36133 Max (BgimL) 2298 84936 181797 180929 91244 Average (BomL) 1570 57482 128432 11:4758 70572 TotalActivity (80) 228 2480 90822 202922 181317 111503 Standard Deviation (ByimL) 259 785 9702 12356 17974 8511 1.54e5 1 23e5 8.2564 6.16€4 3:00€4 0.00 Metrics (Bq/mL) 0 600 900 1200 1500 1800 2100 2400 2700 3300 3600 ALL VOIS Time (second) Add to Report Export to CSV Save As 5 X-Min Max OK Help TAC’s are color coded to the color of the VOI. You can display all TAC’s on the graph or one at a time. You can also rescale the x-axis to zoom in on the bolus region of the input function. 7. Save the IF into the patient database by choosing Save As TrueD: TAC Save As x · Input Function 9.250€ Secondary Capture 6 164€ . BMP File Name Folder Name H.\SiteData\TrueD Metrics (Bq/ml.) 1500 1000 L.L VON Time heco OK Cancel Add to Report Export to CSV Save As SIEMENS Unrestricted | Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2022 Master Template Effective Date 10 Aug 2021 | HILS 2224 Healthineers Page 4 of 6 Job Aid | Multiparametric PET AI: Manual Input Function Generation in TrueD Effective Date: 31-Aug-2022 | HOOD05162003294128 8. VOI’s are automatically saved with a report Volume Registration Click the "Save Visualization Report" Icon MIP Can give a name 3D Quantification for the Report Report VOLID 3 VOI Details True vorLabel Livar Choose "Select Report" to load in a saved report Any VOIs saved with report will load Key linages 9. The manual IF is available in the Patlak Subtaskcard via the dropdown Recon job 1 2 3 4 5 8 Series description PET WB Dynamic Lumped Constant 1.0 Blood Glucose 0.00 mmoUL Display SUV Input Function IF_AORTA_20170808_140205 34.4 Aorta_20170503 174713 Left_Ventrical 20170503_174713 27.1 SUV 12.5 5.2 00:00 00 00:10:35 00:30:50 00:01:15 00:41:40 0:52:05 01:03:30 Time (hmmys) Routine Scan Recon Auto Tasking Patlak SIEMENS Unrestricted | Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2022 Master Template Effective Date 10 Aug 2021 | HILS 2224 Healthineers Page 5 of 6 Job Aid | Multiparametric PET AI: Manual Input Function Generation in TrueD Effective Date: 31-Aug-2022 | HOOD05162003294128 Please note that the learning material is for training purposes only. For the proper use of the software or hardware, please always use the Operator Manual or Instructions for Use (here- inafter collectively “Operator Manual”) issued by Siemens Healthineers. This material is to be used as training material only and shall by no means substitute the Operator Manual. Any material used in this training will not be updated on a regular basis and does not necessarily reflect the latest version of the software and hardware available at the time of the training. The Operator Manual shall be used as your main reference, in particular for relevant safety information like warnings and cautions. Please note: Some functions shown in this material are optional and might not be part of your system. Certain products, product related claims or functionalities (hereinafter collectively “Functionality”) may not (yet) be commercially available in your country. Due to regulatory requirements, the future availability of said Functionalities in any specific country is not guaranteed. Please contact your local Siemens Healthineers sales representative for the most current information. The reproduction, transmission or distribution of this training or its contents is not permitted without express written authority. Offenders will be liable for damages. All names and data of patients, parameters and configuration dependent designations are fictional and examples only. All rights, including rights created by patent grant or registration of a utility model or design, are reserved. © Siemens Healthcare GmbH 2022 Siemens Healthineers Headquarters Siemens Healthcare GmbH Henkestr. 127 91052 Erlangen, Germany Phone: +49 9131 84-0 siemens-healthineers.com SIEMENS Unrestricted | Published by Siemens Healthcare GmbH © Siemens Healthcare GmbH, 2022 Master Template Effective Date 10 Aug 2021 | HILS 2224 Healthineers Page 6 of 6