HM Components, Processing and Consumables on the Dimension® EXL™ 200 and Dimension® EXL™ with LM Integrated Chemistry Systems Video

Welcome to the HM Components processing and consumables on the Dimension EXL 200 and Dimension EXL with LM Integrated Chemistry Systems video. In this video you will learn about the key heterogeneous module or HM components and their functions during sample processing. You will also learn about the HM consumables used during sample processing. The HM module processes chromium based immunoassays for the measurement of specialty analytes of low molecular weight, such as human chorionic gonadotropin HCG. The immunoassay is prepared in the HM area where it is washed, mixed and incubated. The photometric sample probe delivers the immunoassay reactants into cue vets where the test results are read photometrically. For more information about HM processing, please see the Dimension system HM Reaction and features online training to begin sample processing. The vessel holder feeds reaction vessels to the track system where they are loaded onto the incubate wheel by the vessel transfer shuttle. Next, there are two reagent probe picks up and delivers reagents to the reaction vessel. The photometric sample probe picks up and delivers sample to the same reaction vessel on the incubate wheel. The incubate wheel incubates reaction vessel contents. This allows reactants to form an immuno sandwich. The incubate wheel has 45 slots and maintains a temperature of 37 to 39°C. Incubation times may vary according to the particular HM test being run. After incubation is completed, the vessel transfer shuttle moves reaction vessels to the inner wash wheel. At this point, the wash cycle begins by magnetically separating chromium containing bound reactants from unbound reactants in the reaction vessel. Wash station probes aspirate unbound reactants and dispense chemistry wash reagent into the reaction vessel, further separating bound from unbound reactants. Vessel mixers, which are located under the wash wheel, resuspend vessel contents. The mixer can process either a single vessel or two vessels simultaneously. Vortex mixing concludes the wash cycle. The HM module repeats the cycle until four wash cycles have been performed. The R1 reagent probe adds reagents from the flex reagent cartridge to a cuvet. The vessel transfer shuttle moves the reaction vessel back to the incubate wheel. The photometric sample probe transfers immunoassay reactants from the reaction vessel to the same cue VAT. The transfer shuttle moves the used reaction vessels to the waste chute, which then discards the vessels into a waste container. Make sure the waste container liner is fully open and conforms to the inside walls and bottom of the container. Failure to insert the liner properly may result in vessel jams in the waste chute. The HM technologies require periodic replacement of consumables. Please refer to the Dimension System Operator's Guide for instructions on replacing these consumables. Sample probe cleaner, which contains dilute sodium hypochlorite bleach, fills one of the sample probe dual drains. The photometric sample probe performs this extra rinsing step to ensure that it is thoroughly clean. To prevent sample carryover, Sample probe cleaner is located under the film cartridge. Replace the sample probe cleaner when there is less than 5% remaining as indicated on the daily maintenance routine screen. F3. Check HM counts or if an error message appears indicating that the consumable bottle is empty. The volumes of these fluids are monitored by a low level sensor in each container. Chemistry Wash is used to wash away unbound sample and reagents from the immuno sandwich during HM processing. Chemistry Wash is located behind the pump panel. Replace when there is less than 5% remaining as indicated on the daily maintenance routine screen. F3 Check HM counts or if an error message indicates the consumable bottle is empty. The volumes of these fluids are monitored by a low level sensor in each container. Note To prevent possible contamination, do not pool bottles of chemistry wash solution when replacing. This consumable reagent probe cleaner, which contains 0.1 in sodium hydroxide, is pumped to one of the R2 probe dual drains and is used to clean the R2 reagent probe and drain for HM processing. Reagent probe cleaner is located underneath the film cartridge. Replace reagent probe cleaner when there is less than 5% remaining as indicated on the daily maintenance routine screen. F3. Check HM counts or if an error message appears indicating that the consumable bottle is empty. The volumes of these fluids are monitored by a low level sensor in each container. The HM system uses special containers called reaction vessels. The operator loads reaction vessels into the vessel holder and then the vessel feeder and Track system automatically load reaction vessels from the vessel track onto the incubate wheel as needed. When replacing, do not overfill the reaction vessel holder. Filling above the red line may cause jams. Note the dimension EXL 200 Integrated Chemistry System uses only reaction vessels with a plastic tip on the bottom. Access the HM System Counter screen to monitor consumables that need to be replaced. Refer to the Operator's Guide for detailed instructions on how to replace HMM consumables. To access this screen, from the operating menu, select F4 System Prep, then select F6 System Counters and then F6 HMM Counters. You can also access the HMM System Counter screen from the Daily Maintenance Routine screen. From the operating menu, select F4 System Prep, then select F8 Daily Maintenance. On the daily maintenance routine screen, select F3. Check HM Counts to display the HM system counter screen. Flex reagent cartridges contain reagents necessary to perform HM and other tests. The color and lid cover of HM Assay Flex reagent cartridges are specifically designed to protect reagents from light.

341 1500 2044 20000 134 12000 380 48000 36000 0.0 00486019 HM Components, Processing and Consumables on with LM Integrated Chemistry Systems Video Vessel Holder Track Incubate Wheel Transfer Shuttle R2 Probe Photometric HM Sample Probe Vessel Transfer IMT Port Reaction Vessel on Incubate Wheel Wash Wheel Was Wa Wash Probe 2 Vessel Mixer R1 Reagent Probe SIEMENS . CONTENTS 1 Chemistry Wash: Dimension" clinical chemistry system Sample Probe Cleaner Wash Cleaner Chemistry Reagent Probe Reaction Vessels Standby Sampler Idle IMT OK 05/17/24 10:54 Healthineers Dimension Exit Enter labmanager en HETEROGENEOUS MODULE SYSTEM COUNTERS STAT Status Item Fill Level Est Last Replaced Replace Sample Alert Supplies 12-JAN-2023 6:01 NO Rgt Prbe Clnr: 0 % 12-JUN-2023 14:06 QC Alert Smp Prbe Clnr: 93 % Calib Alert Run Count Replace at Home Vessels in Waste: 5-AUG-2020 11:29 NO F1: STORE CHANGES F2: F4: F5: F6 F7: F8: F3 OPERATING MENU PLEASE SELECT AN OPTION USING THE FUNCTION KEYS: At any time, press HELP to get help, or press EXIT to exit a program. To Shut down or Change Operator, press Sign Out or Alt+EXIT. F1: ENTER DATA F2: SAMPLE STATUS F3: TEST RESULTS F4: SYSTEM CHECK F5: PROCESS CTRL F6: SYSTEM CONFIG F7: DIAGNOSTICS F8: SEGMENT STATUS SYSTEM PREPARATION MENU F1: INVENTORY F2: REAGENT PREP F3: IMT F5: TEMP MONITOR F6: SYS COUNTERS F7: PUMP PRIME F8: DAILY MAINT. SYSTEM COUNTERS Installed: 5-AUG-2020 Bootups: 17 Cuvettes: 410 Tests: Dirty windows: Cycles Clean at Last Cleaned Sample Probe: 28-JAN-2024 17:41 Pos: Cycles Replace at Cuvette Cartridge: 12-APR-2023 4:32 Diaphragm: 5-AUG-2020 11:29 Sample Probe Tip: 28-JAN-2024 17:41 R1 Probe Tip: F2: DIAPH CHANGE F3: FILM LOAD F4: CLEAN PROBE F7: RMS COUNTERS 5-AUG-2020 11:29 N F3: F8 F6: System Prep DAILY MAINTENANCE ROUTINES TEMPERATURE CHECK Cuvette: 37.0 C Reagent: 4.0 C HM: 38.0 C Hydration: 4.0 C Reagent (RMS): PUMP PRIME ( 3 Cycles) SYSTEM CHECK (Cuvettes: 11866 Failed QC: 0) EMPTY CUVETTE WASTE CHK Lot: Carton Values: POSITION INITIALS SAMPLE ID SAMPLE FLUID AUTO SAMPLER CHECK CHK Press F3 to see which HM system counters have expired. F1: START F3: CHK HM COUNTS F5: OFFBOARD LOTS F6: INSTRUMENT LOG F7: MAINT LOGS F8: AUTO SETUP F5 MMB Flex EXP Disclaimer Please note that the learning material is for training purposes only. For the proper use of the software or hardware, please always use the Operator Manual or Instructions for Use (hereinafter collectively "Operator Manual") issued by Siemens Healthineers. This material is to be used as training material only and shall by no means substitute the Operator Manual. Any material used in this training will not be updated on a regular basis and does not necessarily reflect the latest version of the software and hardware available at the time of the training. The Operator Manual shall be used as your main reference, in particular for relevant safety information like warnings and cautions. Please note: Some functions shown in this material are optional and might not be part of your system. Certain products, product related claims or functionalities (hereinafter collectively "Functionality") may not (yet) be commercially available in your country. Due to regulatory requirements, the future availability of said Functionalities in any specific country is not guaranteed. Please contact your local Siemens Healthineers sales representative for the most current information. The reproduction, transmission or distribution of this training or its contents is not permitted without express written authority. Offenders will be liable for damages. All names and data of patients, parameters and configuration dependent designations are fictional and examples only. All rights, including rights created by patent grant or registration of a utility model or design, are reserved. Unrestricted | Published by Siemens Healthineers AG | @ Siemens Healthineers AG, 2024 Siemens Healthineers HQ | Siemens Healthineers AG Siemensstr. 3 91301 Forchheim Germany Phone: +49 9191 18-0 siemens-healthineers.com