AI-Rad Companion Brain MR – White Matter Hyperintensities

In the earlier version of Errett companion Brain, amid the product provided. Volumetric information of several brain structures of the patient and its comparison with the normative database of healthy population. In the next new version of this product we are extending the feature set to also provide the quantification of white matter hyperintense lesions from flare and amperage images, which typically are associated with multiple sclerosis. In this slide you can see a typical workflow with added companion Braining Mart. Whenever a patient with suspected Miss is presented, neurologist, after evaluating the clinical symptoms would refer the patient for MRI examination. McDonald's criteria is a clinical guideline which provides the diagnosis of MMS, and it also mentions the reporting of white matter hyperintense lesions in space and time. The standard examinations of MRI, like MP Rage and 3D flare are sent to arid companion branemark for processing, which in turn sends 2 results to the packs the annotated. Lesion map and the quantitative report which are readily available to the radiologist in the reading workflow and for radiology reporting. In this slide, the more detail about this 2 result is shown. The 1st result is DICOM image secondary capture which provides the annotation of white matter hyperintense lesions in different colors as per the four brain regions described in McDonald's criteria and the 2nd result is also a DICOM image series with quantification information like count and volume of the lesion and their distribution into four brain. Agents I would like to also share some. More detail about the work that we did on prototype that went into development of this product. Our prototype is being used in a large multi site clinical consortium called Miss Paths. It aims to collect patient data from a broader Ms population and also better quantify the value of the treatment and improve the outcome of patient in Ms. In this consortium, there are several. Prestigious clinical sites involved who have processed collectively thousands of cases through our prototype and provided very good clinical feedback. Our AI scientists have published several clinical articles based on this work, which are listed here. So to sum up, we are extending a red companion brain emard with a new feature called white matter hyperintensities which is useful for Ms evaluation.

3/21/2018 85 18.97 16.26 26 1.73 0.01 49 0.97 Al-Rad Companion Brain MR (VA40) SIEMENS . Healthineers* White Matter Hyperintensities Patient Neurologist Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria Radiologist White Matter Lesions in MRI Volumetry of brain structures WMH Count, Volume, Location REPORT Al-Rad Companion MRI MPRAGE 3D FLAIR Brain MR Digital Health Unrestricted O Siemens Healthineers, 2021 powered Al-Rad Companion Brain MR - White Matter Hyperintensities Results sent to PACS 2. DICOM Report containing WMH 1. DICOM image series with WMH map lesion count and volume as per 4 brain regions Brain WMH Report - 1/1 Patient Demographics 78yrs Input Data Examination Date 3D-T1-MPRAGE Male 3D-FLAIR Total lesion count Structure Periventricular Lesion Count Juxtacortical Infratentorial Deep white matter Prototype Usage in MS PATHS sponsored by Biogen · Technology-enabled network of MS centers to collect patient data generated from a broad MS population Aims to better quantify the value of treatment and improve patient outcomes in MS Thousands of cases processed Positive Feedback Prototype Publications * Fartaria, Mário João, et al. "Longitudinal analysis of white matter and cortical lesions in multiple sclerosis." Neurolmage: Clinical 23 (2019]: 101938 Dunet, Vincent, et al. "Episodic memory decline in Parkinson's disease: relation with white matter hyperintense lesions and influence of quantification method." Brain imaging and behanvior 13.3 (2019): 810-818 Fartaria, Mário João, et al, "Partial volume-aware assessment of multiple sclerosis lesions." Neurolmage: Clinical 18 (2018]: 245-253 Fartaria, Mário Joao, et al. "Automated detection of white matter and cortical lesions in early stages of multiple sclerosis." Journal of Magnetic Resonance Imaging 43.6 (2016]: 1445-1454 Please note that the learning material is for training purposes only. For the proper use of the software or hardware, please always use the Operator Manual or Instructions for Use (hereinafter collectively "Operator Manual") issued by Siemens Healthineers. This material is to be used as training material only and shall by no means substitute the Operator Manual. Any material used in this training will not be updated on a regular basis and does not necessarily reflect the latest version of the software and hardware available at the time of the training. The Operator Manual shall be used as your main reference, in particular for relevant safety information like warnings and cautions. Please note: Some functions shown in this material are optional and might not be part of your system. Certain products, product related claims or functionalities (hereinafter collectively "Functionality"') may not (yet) be commercially available in your country. Due to regulatory requirements, the future availability of said Functionalities in any specific country is not guaranteed. Please contact your local Siemens Healthineers sales representative for the most current information. The reproduction, transmission or distribution of this training or its contents is not permitted without express written authority. Offenders will be liable for damages. All names and data of patients, parameters and configuration dependent designations are fictional and examples only. All rights, including rights created by patent grant or registration of a utility model or design, are reserved. Siemens Healthcare GmbH 2022 SIEMENS Health Healthineers